LYSOSOMAL STORAGE DISORDERS
Many genetic disorders can be caused by mutations that make proteins less stable or disrupt the normal three-dimensional folding of proteins. These genetic disorders include lysosomal storage disorders (LSDs).
LSDs are caused by mutations that alter a patient’s endogenous enzymes, which may lead to a decrease in protein stability and even misfolding of enzymes. This may cause the deficient enzyme’s substrate to accumulate in the body.
Fabry disease is an inherited LSD caused by deficiency of an enzyme called α-galactosidase A (α-Gal A). The function of α-Gal A is to degrade glycosphingolipids, or sugary-fat material, in lysosomes, including globotriaosylceramide (GL-3, also known as Gb3). Progressive accumulation of GL-3 is believed to lead to the morbidity and mortality of Fabry disease, including pain, kidney failure, heart disease, and stroke.
Pompe disease is an inherited LSD caused by deficiency of an enzyme called acid α-glucosidase (GAA). Reduced or absent levels of GAA lead to the accumulation of the substrate glycogen in the lysosomes of various cells within the body. Progressive accumulation of glycogen is believed to lead to the morbidity and mortality associated with Pompe disease, including muscle weakness and respiratory insufficiency.
EB is a rare genetic disorder that manifests as blistering or erosion of the skin and, in some cases, the epithelial lining of other organs. EB is chronic, debilitating, and can potentially be disfiguring and fatal. There is currently no approved treatment for EB; however, Amicus is committed to addressing this significant unmet need.
SVP, Head of International
Regional Vice President, International
Regional Vice President & General Manager
Willem van Weperen
Regional Vice President, International
Regional Vice President & General Manager
Head of Human Resources, International
Head of Medical Affairs, International
Head of Technical Commercial Operations, International
Head of International Commercial Operations
Head of Patient Advocacy, International
Welcome to the Amicus International careers page, where you will find information on current vacancies and how to apply.
We are a small but growing business establishing a global commercial infrastructure to bring our therapies to patients. As a small business, we need people with great backgrounds, particularly individuals with significant pharmaceutical experience, including orphan drug experience. Applicants should also be comfortable working in a dynamic, start-up environment as this isn't for everyone.
In addition, we work equally hard to maintain the unique culture at Amicus. We are looking for people who can demonstrate key behaviours and traits that we think make Amicus a special place to work including the ability to work in a fast-paced environment, a willingness to take action and make sound, ethical decisions, exceptional communication skills and demonstrated emotional intelligence.
Amicus is at an exciting time as it becomes a global organization. If interested and qualified, we would like to hear from you!
How To Apply
Please send an email with your CV to firstname.lastname@example.org indicating which vacancy you are applying for. Please also include reason for applying, your current location and remuneration details. Additionally, please read through the following:
- We only accept applications via this page from interested candidates for posted positions (no recruitment agencies or other third parties)
- While we would like to provide feedback to all applicants, we can only contact those applicants with whom we would like to talk further
- We will keep all applications on file for 6 months
Finally, thanks for your interest. If you would like more information, please visit our main site www.amicusrx.com
Current Global Openings
Opportunities in Gerrard’s Cross, UK
Opportunities in Munich, Germany
Opportunities in Japan
Amicus Therapeutics UK LTD
Oxford Road, Tatling End Gerrards Cross Buckinghamshire SL9 7AP United Kingdom
Tel: +44 1753 888567
These Terms refer to the following additional items, which also apply to the use of our Site:
Information About Us
AmicusRX.co.uk is a site operated by Amicus Therapeutics UK Ltd (“Amicus”, “we” or “us”). We are a private limited company registered in England and Wales under company number 05541527 and have our registered address at 30 Upper High Street, Thame, Oxfordshire OX9 3EZ, UK. Our main trading address is Phoenix House, Oxford Road, Tatling End, Gerrards Cross, Buckinghamshire SL9 7AP, UK. Our VAT number is [Insert VAT number]. As a pharmaceutical company, we are regulated by the UK Government’s Medicines & Healthcare products Regulatory Agency.
Changes To These terms
Amicus Therapeutics may modify these Terms at any time by amending this page, and such modification shall be effective immediately upon posting on the Site. Your continued access or use of the Site after the modifications have become effective shall be deemed your conclusive acceptance of the modified Terms. Please check this page from time to time to take notice of any changes we make, as they are binding on you.
Changes To Our Site
We may update our Site from time to time, and may change the content at any time. However, please note that any of the content on our Site may be out of date at any given time, and we are under no obligation to update it. We do not guarantee that our Site, or any content on it, will be free from errors or omissions.
Accessing Our Site
Our site is made available free of charge. We do not guarantee that our site, or any content on it, will always be available or be uninterrupted. Access to our Site is permitted on a temporary basis. We may suspend, withdraw, discontinue or change all or any part of our Site without notice. We will not be liable to you if, for any reason, our Site is unavailable at any time or for any period.
You are responsible for making all arrangements necessary for you to have access to our Site. You are also responsible for ensuring that persons who access our Site through your internet connection are aware of these Terms, and other applicable terms and conditions, and that they comply with them.
Our Site is directed to people residing in the UK. We do not represent that content available on or through our Site is appropriate or available in other locations. We may limit the availability of our Site described on our Site to any person or geographic area at any time.
The contents of our Site, including its “look and feel” ( e.g., text, graphics, images, logos, and button icons), editorial content, notices, software (including HTML or XML-based computer programs) and other material, are protected under copyright, trademark, and other laws and treaties around the world. These contents belong or are licensed to Amicus. All rights are reserved.
We hereby grant you the right to view and use our Site subject to these Terms. You may download or print a copy of information provided in the Site for personal use or, if you are a business user, for internal use or distribution only. Our status (and that of any identified contributors) as the authors of content on our Site must always be acknowledged. You must not modify the paper or digital copies of any materials you have printed off or downloaded in any way and you must not use any illustrations, photographs, video or audio sequences or any graphics separately from accompanying text.
Permission to reprint or electronically reproduce any document or graphic in whole or in part for any other purpose is expressly prohibited, unless prior written consent is obtained from us. If you print off, copy or download any part of our Site in breach of these Terms, your right to use our Site will cease immediately and you must, at our option, return or destroy any copies of the materials you have made.
Limitation Of Liability
Nothing in these Terms excludes or limits our liability for death or personal injury arising from our negligence, fraud, fraudulent misrepresentation or any other liability that cannot be excluded or limited by English law.
To the extent permitted by law, we exclude all conditions, warranties, representations or other terms that may apply to our Site or any content on it, whether express or implied. We will not be liable to any user for any loss or damage, whether in contract, tort (including negligence), breach of statutory duty or otherwise, even if foreseeable, arising under or in connection with:
- use of, or inability to use, our Site; or
- use of, or reliance on, any content displayed on our Site.
- If you are a business user, please note that in particular we will not be liable for:
- loss of profits, sales, business or revenue;
- business interruption;
- loss of anticipated savings;
- loss of business opportunity, goodwill or reputation; or
- any indirect or consequential loss or damage.
If you are a consumer, please note that we only provide our Site for domestic and personal use. You agree not to use our Site for any commercial or business purpose and we have no liability to you for any loss or profit, loss of business, business interruption or loss or business opportunity.
We will not be liable for any loss or damage caused by a virus, distributed denial-of-service attack or other technologically harmful material that may infect your computer equipment, computer programs, data or other proprietary material due to your use of our Site or to your downloading of any content on it or on any website linked to it.
We do not guarantee that our site will be free from bugs or viruses. You are responsible for configuring your information technology, computer programs and platform in order to access our Site. You should use your own virus protection software.
You must not misuse our Site by knowingly introducing viruses, trojans, worms, logic bombs or other material that is malicious or technologically harmful. You must not attempt to gain unauthorised access to our site, the server on which our site is stored or any server, computer or database connected to our Site. You must not attack our Site via a denial-of-service attack or a distributed denial-of-service attack. By breaching this provision, you would commit a criminal offence under the Computer Misuse Act 1990. We will report any such breach to the relevant law enforcement authorities and we will cooperate with those authorities by disclosing your identity to them. In the event of such a breach, your right to use our Site will cease immediately.
Links To Our Site
We welcome links to our Site from other web sites; however, you must link to our home page in a way that is fair and legal and does not damage our reputation or take advantage of it. You must not establish a link in such a way as to suggest any form of association, approval or endorsement on our part where none exists. You must not establish a link to our Site in any website that is not owned by you. Our Site must not be framed in any other site, nor may you create a link to any part of our site other than the home page.
Permission is required before we link. To request permission, please contact us at email@example.com. We in no way operate, control or endorse linking sites, and we reserve the right to disallow any such link at any time in our sole discretion.
If you wish to make any use of content of our site other than that set out above, please contact firstname.lastname@example.org.
Third-Party Resources On Our Site
We are happy to provide links to third-party resources in the “Resources” section of our Site. We have obtained permission to provide those links for your personal, non-commercial use, but we disclaim any responsibility for the accuracy, lawfulness or use of those resources, and, unless we state expressly to the contrary, do not endorse any of the opinions or contents contained therein. We will not be liable for any loss or damage that may arise from your use of them.
THIS SITE AND THE INFORMATION IT CONTAINS IS MADE AVAILABLE “AS IS,” WITHOUT WARRANTY OF ANY KIND, EITHER EXPRESS OR IMPLIED. WE MAKE NO REPRESENTATION, WARRANTY OR GUARANTEE THAT THE INFORMATION ON THIS SITE IS UP-TO-DATE, ACCURATE, OR COMPLETE, AND YOU SHOULD NOT RELY ON IT FOR ANY DECISION OR TO TAKE ANY ACTION. WE HEREBY DISCLAIM ANY WARRANTY THAT THE INFORMATION ON THIS SITE WILL BE FREE OF INTERRUPTION, OR THAT THE SITE IS FREE OF VIRUSES, WORMS, TROJAN HORSES OR OTHER CODE THAT MANIFEST CONTAMINATING OR DESTRUCTIVE PROPERTIES. Changes are periodically made to the information herein; these changes will be incorporated in new editions of the Site.
You agree to indemnify, defend and hold harmless Amicus, its officers, directors, employees, agents and affiliates from and against all losses, expenses, damages and costs, including reasonable attorneys’ fees, arising out of or relating to any violation of these Terms or any activity related to use of the Site (including but not limited to infringement of third parties’ worldwide intellectual property rights or negligent or wrongful conduct) by you or any other person accessing the Site on your behalf.
We collect personally identifying information from visitors to our Site if you voluntarily decide to provide it to us through one of the provided e-mail addresses. Visitors are invited to make inquiries about Amicus and our research, or to inquire about job opportunities. We will use the information you provide us in those communications to respond to your inquiry, but will not use or disclose it in any other way without your express consent, except to contractors or service providers who may provide services or perform functions on our behalf – for example, an information technology service provider or human resources consultant. Those contractors and service providers are permitted to use your personal information only for the purpose for which it has been provided and may not disclose it to any other third party except at our express direction and consistently with this paragraph.
This paragraph applies only to information collected from visitors through our Site and not to personal information that Amicus may collect in its research or through any off-line or other activities.
We welcome expressions of interest in employment with Amicus. Amicus does not discriminate in hiring or employment on the basis of race, colour, religion, disability, national origin, age, sex, or any other characteristics protected by applicable federal, state or local law. You understand that an invitation to submit your resume or expression of interest in a job posted on the Site is not intended to, and does not, create a contract between you and Amicus for employment or for any other benefit. You understand that any communication sent by you to Amicus inquiring about employment shall not be considered an application for employment and creates no obligation on the part of Amicus to respond. Should Amicus be interested in exploring employment opportunities with you, we will contact you in response to your inquiry.
Governing Law and Forum
If you are a customer, please note that these Terms, their subject matter and formation (and any non-contractual disputes or claims) are governed by English law. However, if you are a resident of Northern Ireland, you may also bring proceedings in Northern Ireland, and if you are resident in Scotland, you may also bring proceedings in Scotland.
If you are a business, these Terms, their subject matter and formation (and any non-contractual disputes or claims) are governed by English law. We both agree to to the exclusive jurisdiction of the courts of England and Wales.
[Insert Amicus UK trade marks] are [UK registered] trade marks of Amicus.
To inquire about linking to our Site or about trademark or copyright matters or if you have any questions or concerns about these Terms, please contact us at email@example.com.
Our Commitment to Privacy
By visiting [Insert URL] you are accepting, and consenting to, the practices described in this Policy.
For the purpose of the Data Protection Act 1998 (the “Act”), the data controller is Amicus Therapeutics UK Ltd (“Amicus”, “we” or “us”) of Phoenix House, Oxford Road, Tatling End, Gerrards Cross, Buckinghamshire SL9 7AP.
What Information Do We Collect?
When you visit our Web site you may provide us with two types of information, which we may collect and process:
1) Information you give to us (personal information you knowingly choose to disclose that is collected on an individual basis). You may give us information about you by filling in forms on our Web site [Insert URL] (“our Web site”) or by corresponding with us by phone, email or otherwise. The information you give us may include your name, address, email address and phone number [Insert any other information that users may provide to Amicus UK via its website], and
2) Information we collect about you (Web site use information collected on an aggregate basis as you and others browse our Web site). With regard to each of your visits to our Web site, we may automatically collect technical information, including the Internet protocol (“IP”)address used to connect your computer to the Internet, your browser type and version, time zone setting, browser plug-in types and versions, operating system and platform. Similar to other commercial Web sites, our Web site may in the future use a standard technology called "cookies" (see explanation below, "What Are Cookies?") and Web server logs to collect information about how our Web site is used. Information gathered through cookies and Web server logs may include the date and time of visits, the pages viewed or searched for, page response times, download errors, page interaction information (such as scrolling, clicks and mouse-overs), time spent at our Web site, the Web sites visited just before and just after our Web site, methods used to browse away from our Web site and any phone number used to call our customer service number. This information is collected on an aggregate basis. None of this information is associated with you as an individual.
We may also receive information about you from other sources. We receive information about you if you use any of the other websites the Amicus group operates or the other services we provide. We also work closely with third parties (including, for example, [business partners, sub-contractors in technical services, analytics providers, search information providers) and may receive information about you from them.
How Do We Use the Information That You Provide to Us?
We use information held about you in the following ways:
1) Information you give to us. We will use this information in the following ways:
- to make our Web site available to you and to provide you with content that we feel may interest you;
- to provide you with services that you request and to respond to any enquiries that you submit through our Web site;
- to notify you about changes to our service;
- to ensure that content from our Web site is presented in the most effective manner for you and your device.
2) Information we collect about you. We will use this information:
- to administer our Web site and for internal operations, including troubleshooting, data analysis, testing, research, statistical and survey purposes;
- to improve our site to ensure that content is presented in the most effective manner for you and your computer;
- to allow you to participate in any interactive features of our service, when you choose to do so; and
- as part of our efforts to keep our site safe and secure.
3) Information we receive from other sources. We may combine this information with information you give us, and information we collect, about you. We may use this information and the combined information for the purposes set out above (depending on the types of information we receive).
What Are Cookies?
Cookies are a feature of Web browser software that allows Web servers to recognize the computer used to access a Web site. Cookies are small pieces of data that are stored by a user's Web browser on the user's hard drive. Cookies can remember what information a user accesses on one Web page to simplify subsequent interactions with that Web site by the same user or to use the information to streamline the user's transactions on related Web pages. This makes it easier for a user to move from Web page to Web page and to complete commercial transactions over the Internet. Cookies should make your online experience easier and more personalized.
How Do We Use Information We Collect from Cookies?
We use software tools such as Web server logs to gather information about our Web siteusers' browsing activities, in order to constantly improve our Web site and better serve our customers. This information assists us in designing and arranging our Web pages in the most user-friendly manner and to continually improve our Web site to better meet the needs of our customers and prospective customers.
Web server logs allow us to count how many people visit our Web site and evaluate our Web site's visitor capacity. We do not use these technologies to capture your individual email address or any personally identifying information about you.
Where Do We Store Your Personal Data?
The data that we collect from you may be transferred to, and stored at, a location outside the European Economic Area (“EEA”). It may also be processed staff operating outside the EEA who work for us or for one of our affiliates for the purposes outlined above. We will take all steps reasonably necessary to ensure that your data is treated securely and in accordance with this Policy.
However, unfortunately, the transmission of information via the Internet is not completely secure. Although we will do our best to protect your personal data, e-mail that you may send to us, or forms that you may submit, may not be secure unless we advise you that security measures will be in place prior to your transmitting the information. For that reason, we ask that you do not send confidential information such as Social Security or account numbers to us through an unsecured email or forms. Once we have received your information, we will use strict procedures and security features to try to prevent unauthorised access. All information you provide to us is stored on secure servers.
Do We Disclose Information to Outside Parties?
We may share your personal information with any member of our group, which means oursubsidiaries, our ultimate holding company and its subsidiaries, as defined in section 1159 of the Companies Act 2006.
We have share your information with selected third parties, including:
- Business partners, suppliers and sub-contractors for the performance of any contract we enter into with them or you.
- Analytics and search engine providers that assist us in the improvement and optimisation of our Web site.
We may disclose your personal information to third parties:
- In the event that we sell or buy any business or assets, in which case we may disclose your personal data to the prospective seller or buyer of such business or assets.
- If Amicus or substantially all of its assets are acquired by a third party, in which case personal data held by it about its customers will be one of the transferred assets
What About Legally Compelled Disclosure of Information?
We may disclose information when legally compelled to do so, in other words, when we, in good faith, believe that the law requires it or for the protection of our legal rights.
What About Other Web Sites Linked to Our Web Site?
We are not responsible for the practices employed by Web sites linked to or from our Website nor the information or content contained therein. Often links to other Web sites are provided solely as pointers to information on topics that may be useful to the users of our Web site. Amicus Therapeutics is committed to improving the lives of patients and families affected by rare and orphan diseases.